5 Tina Fey and Amy Poehler
Few celebrity friends remain as closely linked on screen as Tina Fey and Amy Poehler. The two co-starred on “Saturday Night Live” from 2001 to 2010. Their comedic personalities create a natural connection and chemistry, which has contributed to their involvement in film roles and as hosts of film and television award shows. In October 2012, they collaborated to auction off a night out with themselves that raised $46,000 for an autism charity, according to a December 2012 Yahoo! Movies article.
4 Cameron Diaz and Drew Barrymore
In some cases, it isn’t shared film experiences that strengthen the bonds between celebrity friends, but real-life events. This was the case for “Charlie’s Angels” co-stars and friends Cameron Diaz and Drew Barrymore, who headed to Mexico in March 2013 for a post-pregnancy fitness retreat. Barrymore, who married Will Kopelman in June 2012, gave birth to baby Olive in September 2012. Fellow actress Reese Witherspoon—who gave birth to son, Tennessee around the same time—joined the pair for the girls’ getaway.
3 Brad Pitt and George Clooney
Brad Pitt and George Clooney are almost as prominent as Affleck and Damon in the Hollywood best friends category. The two have grown close as they have co-starred in a number of films and share a passion for social causes and philanthropy. The “Ocean’s 11” trilogy and the 2008 film “Burn After Reading” are prominent movies in which the two have appeared together. In a September 2011 “US Weekly” article, Clooney explained that Pitt constantly pranks him. The two also enjoy riding motorcycles together.
2 Jennifer Aniston and Courteney Cox
In appropriate fashion, the real life best friendship between Jennifer Aniston and Courteney Cox began when they starred in the hit television sitcom “Friends” from 1994 to 2004. While some actors grow apart from co-stars quickly after a show or movie ends production, this pair of actresses have generally remained close. Aniston is even the godmother to Cox’s daughter Coco, whose father is Cox’s ex-husband David Arquette.
1 Ben Affleck and Matt Damon
Ben Affleck and Matt Damon are a rare celebrity duo—they were friends long before they both became famous. The two lived near each other in Cambridge, Massachusetts. The 1997 film “Good Will Hunting,” which the pair co-wrote, co-directed and co-starred in, simultaneously launched their film careers. The two have remained closely linked in film and in friendship ever since.